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Ruth de Diego-Balaguer, Catherine Schramm, Isabelle Rebeix, Emmanuel Dupoux, Alexandra Durr, Alexis Brice, Perrine Charles, Laurent Cleret de Langavant, Katia Youssov, Christophe Verny, Vincent Damotte, Jean-Philippe Azulay, Cyril Goizet, Clémence Simonin, Christine Tranchant, Patrick Maison, Amandine Rialland, David Schmitz, French Speaking Huntington Group, Charlotte Jacquemot, Bertrand Fontaine, Anne-Catherine Bachoud-Lévi
COMT Val158Met Polymorphism Modulates Huntington's Disease Progression
www.plosone.org
www.plosone.org
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q
1 j
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0 w
7.4999 0 0 6.6659 271.559 334.4314 cm
BT
/F9 1 Tf
1 TL
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[(%)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 277.3417 330.0094 cm
BT
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[(B)]TJ
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0 g
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ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 364.5921 230.4566 cm
BT
/F9 1 Tf
1 TL
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[(%)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 370.3748 225.9779 cm
BT
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[( )11()8()-7(\r)1()]TJ
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0.83 0.64 0.02 0 k
[(//)]TJ
0 g
[( #)]TJ
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[()8( )11()-4()19()-5()-2(C)]TJ
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[()1(#)4()7()-4()11()7($)]TJ
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[(' )]TJ
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[(*)]TJ
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[(\(\(,-.)]TJ
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[( \),)]TJ
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 250.2425 177.6188 cm
BT
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1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 254.2677 173.9905 cm
BT
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1 TL
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[()35(//)]TJ
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3.0443 0 Td
[(=)97(\r)]TJ
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[(\r)-9()1()-4()12()-2()18()6(\r)-6()]TJ
3.9855 0 Td
[()-4()4(\r)]TJ
1.474 0 Td
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4.388 0 Td
[()-9(\r)1()-2(+)8(\r)-6(\r)1()]TJ
3.4923 0 Td
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1.6838 0 Td
[(\r)2(*)-9(\r)-6()-6()6(\r)-6()]TJ
3.702 0 Td
[()6()7(\r)]TJ
1.5307 0 Td
[()18()]TJ
0.9638 0 Td
[( )11()8()-7(\r)1()]TJ
2.347 0 Td
[()8()4()]TJ
1.7178 0 Td
[()-4()4(\r)]TJ
-35.359 -1.2982 Td
[()6()7(\r)]TJ
1.5307 0 Td
[()18()]TJ
0.9637 0 Td
[( )11()8()-7(\r)1()]TJ
2.3471 0 Td
[()11()13( )15()-3()2()2(\r)-6()]TJ
3.7813 0 Td
[()1()]TJ
1.0261 0 Td
[( )11()1()]TJ
1.6044 0 Td
[()-2()18()-6()9()-5()1()-7(\r)]TJ
3.6397 0 Td
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4.5184 0 Td
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3.9629 0 Td
[()-1( )11()-4()13(\r)5()-2()18()-5()2( )11()]TJ
4.5807 0 Td
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4.337 0 Td
[(")11()-7(#)]TJ
-34.9395 -1.2983 Td
[()]TJ
0.6576 0 Td
[()4(\r)-5()1()5()1()13(\r)]TJ
3.5546 0 Td
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1.3776 0 Td
[()-1( )11()4()-1( )11()13()-2()8()4()-1(\r)6(!)]TJ
5.5161 0 Td
[(')1()4(\r)]TJ
1.7859 0 Td
[(")11()-7()]TJ
1.8651 0 Td
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[( )5()11()-6()8()1()4(\r)-6()]TJ
3.702 0 Td
[()15()]TJ
1.1793 0 Td
[()]TJ
0.6576 0 Td
[()-2(+)8( \(+)1()18()]TJ
3.634 0 Td
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2.6985 0 Td
[(\r)1()-11()8(\r)-6()-6()]TJ
2.3585 0 Td
[()4( )-9()2(\r)5()]TJ
2.7212 0 Td
[()]TJ
0.83 0.64 0.02 0 k
[(/)]TJ
0 g
[( !)]TJ
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-32.2126 -1.3039 Td
[()-28()10(\r)7()-6(\n)6()17()-6(\n\r)-3()-4()]TJ
5.6465 0 Td
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3.4695 0 Td
[()10()]TJ
1.0659 0 Td
[(\n)2()-10()-7()2()-10()]TJ
3.1181 0 Td
[()10()7()-3()-6()7()1()4(\n)-6()10(\r)]TJ
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5.9527 0 Td
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1.7801 0 Td
[()2( )11()8()-5()12()10()2()1()1()3()-4()]TJ
5.0683 0 Td
[()8()3()-4()7()1()2()3()]TJ
3.3392 0 Td
[(+)1()1()]TJ
1.7008 0 Td
[()-1( )11()4()12()2()-6()6(\r)-6()]TJ
-32.3373 -1.2983 Td
[( )11()]TJ
1.2585 0 Td
[(3%)]TJ
2.143 0 Td
[()-3()3()2()12()]TJ
2.2279 0 Td
[( )11()]TJ
1.0148 0 Td
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1.474 0 Td
[(/$&)]TJ
1.6555 0 Td
[()]TJ
1.7121 0 Td
[()7(\r)1()4(\r)]TJ
2.0523 0 Td
[()-3()8()-4()-4()2(\r)1()7()]TJ
3.2144 0 Td
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0.9581 0 Td
[()2(\r)-5()1()5()]TJ
1.9899 0 Td
[()-2(+)8( )]TJ
1.7008 0 Td
[()-3()3()2()12()]TJ
2.2337 0 Td
[()8()4()]TJ
1.7234 0 Td
[()8( )11()]TJ
1.3777 0 Td
[(+)-7()2()2()6()]TJ
2.6362 0 Td
[()-4()4(\r)]TJ
1.474 0 Td
[()-2()18()6(\r)]TJ
1.8992 0 Td
[( )11()]TJ
-34.7411 -1.2982 Td
[( )11()8()-7(\r)1()]TJ
2.347 0 Td
[(+)1()1()]TJ
1.7008 0 Td
[(:)-4()4( )15(+)-3(!)]TJ
-2.8516 -1.3039 Td
[(=)97(\r)]TJ
1.6101 0 Td
[()-1( )11()19()-5()8()13(\r)-6()]TJ
4.2121 0 Td
[()11()13( )1()-5()13(\r)2()5()2()2( )11()]TJ
4.8812 0 Td
[( )15()8(\r)1()]TJ
1.9616 0 Td
[()-5()1()4(\r)]TJ
2.0126 0 Td
[()-9(\r)1()-2(+)8(\r)-6(\r)1()]TJ
3.4922 0 Td
[()-5()13( )11()12()1(#)]TJ
3.1748 0 Td
[()15()]TJ
1.1792 0 Td
[()-3()-4()2()-6()-5()-2()18()-5()1()8()]TJ
4.5128 0 Td
[()-4()4(\r)]TJ
1.474 0 Td
[( )15()8(\r)1()-4()-5()]TJ
2.897 0 Td
[()6()3()8()8()7(\r)]TJ
3.0273 0 Td
[()1()]TJ
-35.6311 -1.2983 Td
[()4( )11()6( )11()64(#)]TJ
2.9196 0 Td
[()-7()1()4()-6()-5()2( )11()3()-4()6(#)]TJ
4.507 0 Td
[()-9(\r)5()3()18()-3()2( )11()-4()]TJ
4.3767 0 Td
[()8()4()]TJ
1.7234 0 Td
[()-1( )1()-5()2()12()-5()7()8(\r)]TJ
3.8381 0 Td
[()2( )11()3()8()1()8()]TJ
3.6623 0 Td
[()-9(\r)1()]TJ
1.5194 0 Td
[()8(\r)-5()8()]TJ
1.8992 0 Td
[()2()1()4()-1(\r)]TJ
2.2224 0 Td
[()-4()4(\r)]TJ
1.474 0 Td
[()-2()18()6(\r)]TJ
1.8992 0 Td
[( )11()]TJ
1.0091 0 Td
[( )11()8()-7(\r)1()-1(!)]TJ
2.5682 0 Td
[()-6( )11()3()8()1()8()]TJ
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 416.1826 745.7952 cm
BT
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1 TL
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3.1606 0 Td
(Polymorphi)Tj
4.9607 0 Td
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1.552 0 Td
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0.985 0 Td
(Huntington)Tj
4.7977 0 Td
('s)Tj
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(Disease)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
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1 TL
0 0 Td
(PLOS)Tj
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2.3812 0 Td
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0.4819 0 Td
(DOI:10.1)Tj
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